Project Description

ONCODIR

ONCODIR – Evidence-based Participatory Decision Making for Cancer Prevention through implementation research

The ONCODIR project is tackling the rising issue of colorectal cancer (CRC), especially in lower-income populations. They’re using a multidisciplinary approach, including AI and social sciences, to develop personalized cancer prevention programs. They aim to make these programs cost-effective, accessible, and beneficial.

They will test their methods in five EU countries and work closely with various partners to achieve their goals, contributing to cancer prevention and early detection efforts.

EFPC role:

WP1: Project Management.

See for the full list of consortium partners the project website https://www.oncodir.eu/consortium/

WP2: Participatory Implementation Research Framework and System Co-Design (INCLIVA) = input and feedback to the co-design of the system and identifies behavioural barriers and preferences through design thinking workshops and targeted focus groups with its network of experts in the field, patients’ representatives.

T2.2. Onset System Co-design and Continuous System Adaptation on end-user needs (M04-M38) T2.2 is responsible for translating the user requirements, both functional and non-functional requirements and technical KPIs to be followed during the development cycles of all ONCODIR solutions. The system is required to adhere to performance levels, which determine the communication and processing decisions made in the design phase. This task will create the architecture and high-level design of all ONCODIR subsystems. It will describe the overall architecture of the system, including the databases, interfaces, communications and data flow exchanges. End users and stakeholders will determine system design with their feedback based on a participatory approach. 4 number of Design Thinking Workshops with the end-users, for collection of requirements initially and showcase ONCODIR tools and prototypes and receive feedback before the deployment to pilot testing. Roles: POLA leads and chairs the design thinking workshops.

EFPC = to provide input and feedback and insight during the design thinking workshops and participate in developing cycles of ONCODIR solutions

T2.4. Behavioural barriers identification, preferences assessment, and equitable target population impact groups (M4-M18) T2.4 is responsible for identifying the relevant social (including cultural as well as lifestyle aspects) and economic impact factors for citizens’ health-related quality of life. Variables under investigation include cultural, social and technological aspects, as well as, existing mechanisms implemented by governments, policy makers and other actors. Targeted focus groups with European and national patient representatives, scientists and other relevant actors and a panEuropean population survey will be implemented to facilitate this task. Roles: ECPC leads the research and all partners contribute.

EFPC = help identification – participating in targeted focus groups with patient representation, professionals, scientist, policy makers. ECPC creates survey – we give feedback and disseminate it.

WP5: Financial, Clinical and Political Analyses for ONCODIR Adoption (UNIROJA) = expertise and input in EU healthcare systems – insights on policy frameworks, guidelines, and strategies for primary care and cancer prevention,

T5.3. Living Guidelines and Improved Prevention Strategies for ONCODIR CRC interventions adoption in EU Healthcare systems (M15-M42) Task 5.3 main goal is to build on and extend further the: a) current CRC guidelines/recommendations in terms of prevention proposed both by the national cancer strategies b) the EU-CRC cancer strategy on CRC, c) The potential adoption of ONCODIR suggestions, ideas and methodologies applied in tackling behavioural factors that have significant impact on improved prevention strategies for other cancer types as well. Logistic regression analysis will be applied on dimensions such as gender, age, marital status, educational level, monthly household income, employment type, alcohol drinking, smoking, body mass index group, chronic disease, and subjective health status will be investigated aiming to improve CRC prevention policies. Roles: LSMU leads with the participation/contributions of citizens, clinical partners and policy makers.

EFPC = contribute to development of living guidelines and improve prevention strategies for the adoption of the interventions in EU healthcare systems

EFPC = expertise and input collaboration with citizen, partners & policy makers.

WP6: Long-lasting Validation of ONCODIR Solutions and Methodologies and End-user upskilling (LSMU) =  validate and evaluate solutions, provide training to end-users, collect feedback from citizens and policy makers.

T6.2. End user Training and upskilling (M16-M42) Task 6.2 provides training and support to all pilot scale studies. Training manuals, videos and communication packages will be given prior to the implementation related to ONCODIR’s pilot test cases. Questionnaires related to medical and usability aspects will be prepared also in order to capture and analyse users’ feedback on the trial specifics. Hands-on and potentially virtual training will be provided in each pilot site by the technical and other experts of the consortium. Roles: BEIA leads the training and upscaling activities, while all technical partners will provide training support to patients and clinical experts with respect to their offerings by editing manuals and short reports. All medical partners will also provide support/training on their methods.

EFPC = ensure primary care perspectives are incorporated into training materials and provide support to pilot studies.

WP7: Synergistic Impact creation & Bottom-up Innovation (SYNYO ) = communication and dissemination, engage key stakeholders.

Task 7.1 Dissemination, communication and stakeholder identification (M1-M42) D7.1, D7.2: will build upon the activities outlined in Section 2.2. It will include (i) the development of project branding, and the design, development and regular update of the project website and social media channels (ii) the analysis to identify all relevant stakeholders, their interests and motivations, and the potential benefits that the project will provide to each stakeholder group; (iii) specific messages for the different stakeholders (e.g., benefits that the project provides to each stakeholder) and the specific communications channels; (iv) attending, organising and presenting at third-party events, conferences, workshops, webinars and stakeholder meetings to disseminate the project’s results, as well as writing peer-reviewed journals and articles as well as non-academic outputs such as White papers, brochures, and similar on the project’s results; and (v) Monitoring and Evaluating the plan’s implementation. Roles: SYNYO leads all activities with the support of All consortium partners.

EFPC = dissemination

Colorectal cancer (CRC) is one of the most common cancer types and its increased occurrence may be attributable to adverse health behaviors, especially in lower socioeconomic status populations. Stemming from the specific risk factors identified with CRC, ONCODIR integrates multidisciplinary research methods from health policy analytics; social and behavioural science; AI-powered multi-omics and retrospective data analytics as well as decision support theories to deliver evidence-based cancer prevention programmes and innovative AI-powered personalised prevention approaches. ONCODIR recognises that the evaluation of the ONCODIR prevention programmes needs to address cost effectiveness, affordability and cost benefit parameters. Thus it will also investigate cost balancing and demand generating financial schemes that will lead to enhanced CRC prevention programmes. The coherent technological ecosystem that ONCODIR is developing is based on robust AI trustworthiness and privacy preserving principles to deploy recommendation services that will be specified by citizens, health policy actors and SSH experts, during three design thinking workshops. SSH research will address aspects such as the life-status, nutritional and social habits in tandem with Economics, Sociology and Local/Regional Cultural identity and Ethics. ONCODIR’s results will be validated in three Laboratory Integration Tests (LITs) and three Large-scale Intervention Pilots (LIPs) in five EU member states, with the active involvement of medical scientists, health care providers, foundations and consortium experts.

The ONCODIR consortium is coordinated by ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS (CERTH) and composed of 27 complementary partners, coming from multidisciplinary research, technological and SSH domains, with a proven track record of high-quality research capacity. The carefully structured workplan for 42 months, embodies a holistic approach toward meeting the ONCODIR objectives and delivering feasible policy-supporting outcomes of significant exploitation potential. This action is part of the Cancer Mission cluster of projects on ‘Prevention and early detection.

Grant by THE EUROPEAN HEALTH AND DIGITAL EXECUTIVE AGENCY (HADEA) under the European Commission. Grant Agreement